Aging and cancer are biologically intertwined processes: aging is the dominant risk factor for most human malignancies, and many of the molecular hallmarks of aging overlap with those of carcinogenesis. Across a lifetime, somatic cells accumulate DNA damage, epigenetic drift, telomere attrition, mitochondrial dysfun…
Aging and cancer are biologically intertwined processes: aging is the dominant risk factor for most human malignancies, and many of the molecular hallmarks of aging overlap with those of carcinogenesis. Across a lifetime, somatic cells accumulate DNA damage, epigenetic drift, telomere attrition, mitochondrial dysfunction, and chronic low-grade inflammation (often termed inflammaging), which together expand the pool of mutated clones from which tumors can arise. Senescent cells contribute through the senescence-associated secretory phenotype, paradoxically suppressing some tumors while promoting others within an aged tissue microenvironment. Sirtuin signaling (SIRT1) and telomerase activity are frequently studied as nodes linking cellular longevity to proliferative control, and immune senescence reduces tumor surveillance in older individuals. Clinically, oncogeriatrics addresses the management of cancer in elderly and multimorbid patients, where comorbidity, frailty, and altered drug tolerance shape treatment decisions and the challenge of managing multiple concurrent neoplasms. Research in this area spans in vitro models of anti-aging and longevity, geriatric oncology populations, sarcopenia and muscle dysfunction in healthy aging, and proteomic and genomic techniques applied to cancer diagnostics and personalized medicine. The journal publishes peer-reviewed work examining the mechanistic and clinical intersections of biological aging and tumor biology.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 22 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Aging and Cancer, linking to each citing work.