Metabolic disorders are conditions that disrupt the body's normal biochemical processing of nutrients and energy, arising when enzymatic, hormonal, or regulatory pathways governing the metabolism of carbohydrates, lipids, proteins, or other substrates malfunction. They encompass disorders of glucose regulation such …
Metabolic disorders are conditions that disrupt the body's normal biochemical processing of nutrients and energy, arising when enzymatic, hormonal, or regulatory pathways governing the metabolism of carbohydrates, lipids, proteins, or other substrates malfunction. They encompass disorders of glucose regulation such as insulin resistance and diabetes, dyslipidaemias including familial combined hyperlipidaemia, the clustering of risk factors known as metabolic syndrome, disorders of uric acid and amino-acid metabolism, and obesity, and they may be inherited or acquired through diet, lifestyle, and disease. Their importance increases with age, as metabolic regulation deteriorates and chronic metabolic disturbance contributes to cardiovascular disease, hepatic dysfunction, and other age-related conditions, linking metabolic health closely to the biology of ageing. Management combines dietary and lifestyle modification, correction of underlying biochemical abnormalities, and pharmacological therapy, informed by molecular understanding of pathogenesis and by biomarkers of metabolic and vascular risk. The peer-reviewed research collected under this topic addresses the molecular and metabolic pathogenesis of familial combined hyperlipidaemia and metabolic syndrome, anti-ageing and longevity interventions affecting metabolic biomarkers, amino acids in liver disease, nutrition and lifestyle interventions to reduce cardiometabolic risk, insulin resistance in polycystic ovary syndrome, hyperuricaemia, and early vascular ageing linked to metabolic phenotype, reflecting the field's integration of biochemistry, nutrition, and the management of disordered energy and substrate metabolism across the lifespan and in the context of ageing.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 24 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Metabolic Disorders, linking to each citing work.