Research Topic · Peer-Reviewed

Alcoholic Liver Disease

Alcoholic liver disease is the spectrum of hepatic injury caused by chronic, excessive alcohol consumption. It progresses through overlapping stages that begin with hepatic steatosis (fatty liver), in which triglycerides accumulate within hepatocytes, and may advance to alcoholic hepatitis, characterized by inflamma…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 33× across the literature 🔖 ISSN 2997-1977 🗓 Reviewed July 2026

Overview

Alcoholic liver disease is the spectrum of hepatic injury caused by chronic, excessive alcohol consumption. It progresses through overlapping stages that begin with hepatic steatosis (fatty liver), in which triglycerides accumulate within hepatocytes, and may advance to alcoholic hepatitis, characterized by inflammation and hepatocellular necrosis, and ultimately to fibrosis and cirrhosis with irreversible scarring and loss of function. The underlying mechanisms involve the oxidative metabolism of ethanol to acetaldehyde, generation of reactive oxygen species, depletion of antioxidants, altered lipid handling, and activation of inflammatory and fibrogenic pathways; nutritional deficiencies and genetic factors modulate individual susceptibility. Decompensated disease manifests as jaundice, ascites, portal hypertension, coagulopathy, and encephalopathy, and predisposes to hepatocellular carcinoma. Diagnosis combines history of alcohol use with liver enzyme and biochemical testing, imaging, elastography to estimate stiffness, and biopsy when needed; circulating markers such as TREM2 are being investigated. Management centers on abstinence, nutritional support, treatment of complications, and, in advanced cases, liver transplantation. The associated literature reflects related concerns in hepatology, including chronic liver disease epidemiology, vitamin D status in liver disease, biomarkers of alcohol use disorder, and the contribution of diet, situating alcoholic liver disease within the broader study of chronic hepatic injury and metabolic health.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 10 articles above have been cited 33 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Alcoholic Liver Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Diseases (ISSN 2997-1977).

Journal editorial board
Madalena Barroso · Germany VASSILIKI PITIRIGA · Greece Andrzej Prystupa · Poland

This page summarises published research for orientation; it is not medical or professional advice.