Ovarian cancer is a group of malignant neoplasms arising from the ovary, encompassing epithelial carcinomas (the most common, including high-grade serous subtypes), germ cell tumors, and sex cord-stromal tumors. It is among the most lethal gynaecological malignancies, largely because nonspecific early symptoms and t…
Ovarian cancer is a group of malignant neoplasms arising from the ovary, encompassing epithelial carcinomas (the most common, including high-grade serous subtypes), germ cell tumors, and sex cord-stromal tumors. It is among the most lethal gynaecological malignancies, largely because nonspecific early symptoms and the absence of effective population screening lead to advanced-stage diagnosis. Pathogenesis involves accumulated genetic and epigenetic alterations, with hereditary predisposition linked to germline variants in BRCA1/BRCA2 and other homologous-recombination genes; functional and structural classification of variants of uncertain significance is therefore central to risk assessment. Management combines cytoreductive surgery with platinum-based chemotherapy, increasingly informed by molecular biomarkers and targeted agents. The peer-reviewed research collected here engages several of these dimensions, including high-throughput mass-spectrometry feature-weighting approaches to ovarian cancer identification, analysis of a BRCA1 missense variant of uncertain clinical significance, characterization of rare ovarian lesions such as non-specific steroid cell tumors and coexisting mature cystic teratoma with endometrioma, and pH-sensitive nanomedicine strategies for gynaecological cancers. Related work on microRNA-based diagnostics and broader carcinogenesis themes reflects the field's emphasis on early detection, biomarker discovery, and tumor biology. Collectively these contributions underscore the importance of molecular diagnostics, hereditary risk evaluation, and novel therapeutic delivery in improving ovarian cancer outcomes.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Ovarian Cancer, linking to each citing work.