Chromatin is the complex of DNA and associated proteins, principally histones, that packages the genome within the eukaryotic nucleus. DNA wraps around histone octamers to form nucleosomes, which condense into higher-order structures that compact the genetic material and regulate access to it. Chromatin organization…
Chromatin is the complex of DNA and associated proteins, principally histones, that packages the genome within the eukaryotic nucleus. DNA wraps around histone octamers to form nucleosomes, which condense into higher-order structures that compact the genetic material and regulate access to it. Chromatin organization is dynamic: covalent histone modifications, DNA methylation, nucleosome positioning, and chromatin remodeling control gene expression, replication, and repair, providing a major layer of epigenetic regulation. Aberrant chromatin states are implicated in development, ageing, and disease, including cancer and neurodegeneration. Research in this area connects transcriptional regulation, epigenetic mechanisms, and the control of gene expression through binding of regulatory factors. The journal publishes peer-reviewed work relevant to gene regulation and epigenetics, including studies of transcription-factor binding sites and regulatory single-nucleotide polymorphisms, epigenetic regulation of gene expression in disease, signaling pathways in cell differentiation, molecular control of embryonic development, and the conservation and architecture of genes. This body of work examines how the packaging and regulatory context of DNA shape gene activity in development and disease, reflecting the central role of chromatin and its modifications in determining which genes are expressed, and the relevance of these processes to understanding cellular function and pathology.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 79 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Chromatin, linking to each citing work.