Research Topic · Peer-Reviewed

Allergy

Allergy is a hypersensitivity reaction in which the immune system responds inappropriately and excessively to normally harmless environmental, dietary, or pharmacological substances known as allergens. The classic mechanism is type I, IgE-mediated hypersensitivity, in which prior sensitization generates allergen-spe…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 20× across the literature 🔖 ISSN 2577-137X 🗓 Reviewed July 2026

Overview

Allergy is a hypersensitivity reaction in which the immune system responds inappropriately and excessively to normally harmless environmental, dietary, or pharmacological substances known as allergens. The classic mechanism is type I, IgE-mediated hypersensitivity, in which prior sensitization generates allergen-specific IgE that binds mast cells and basophils; on re-exposure, allergen crosslinking triggers degranulation and the release of histamine and other mediators, producing urticaria, angioedema, rhinitis, and, at its most severe, anaphylaxis. Beyond IgE-mediated responses, the Gell and Coombs framework classifies hypersensitivity into types I through IV, including antibody-mediated, immune-complex, and delayed T-cell-mediated reactions; the last underlies allergic contact dermatitis and many delayed drug eruptions. Drug hypersensitivity is a major clinical concern, encompassing immediate and delayed reactions, cross-reactivity among related agents such as NSAIDs and COX-2 inhibitors, and reactions to medical adhesives and other compounds. Diagnosis draws on history, skin and patch testing, in vitro assays, and lymphocyte stimulation testing to identify culprit agents and mechanisms, alongside standardized adverse drug event reporting. Manifestations range across cutaneous, respiratory, and systemic systems. The journal publishes peer-reviewed research on drug hypersensitivity, contact dermatitis, patch testing, and the mechanisms and diagnosis of allergic disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 20 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Allergy, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Immunization (ISSN 2577-137X).

Journal editorial board
Giuseppe Murdaca · Italy Harunor Rashid · Australia Ming Tan · United States

This page summarises published research for orientation; it is not medical or professional advice.