Research Topic · Peer-Reviewed

Cancer Recurrence

Cancer recurrence is the return of malignant disease after a period of apparent remission following initial treatment, arising from residual cancer cells that survive therapy and later resume proliferation. It may be local, at or near the original site, regional, in nearby lymph nodes, or distant, as metastatic spre…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 29× across the literature 🔖 ISSN 2639-1716 🗓 Reviewed July 2026

Overview

Cancer recurrence is the return of malignant disease after a period of apparent remission following initial treatment, arising from residual cancer cells that survive therapy and later resume proliferation. It may be local, at or near the original site, regional, in nearby lymph nodes, or distant, as metastatic spread to other organs, and it represents one of the central challenges in oncology because it can occur after variable intervals and is often difficult to predict and to prevent. The biological basis of recurrence lies in minimal residual disease: small populations of surviving tumour cells, including those with stem-like or treatment-resistant properties, that persist below the threshold of detection. The perioperative period is recognised as a critical window during which residual cells may progress, influenced by surgical, immunological, and molecular factors. Recurrence is studied across many tumour types, including breast, colorectal, lung, and pancreatic cancers, where biomarkers and clinical predictors are sought to estimate risk and guide surveillance. The evolving properties of tumour cells, and adaptive changes within the host, contribute to the persistence and re-emergence of disease. Management depends on early detection, risk stratification, and strategies to suppress residual disease, alongside attention to the psychological impact of recurrence. Understanding its mechanisms is essential to improving long-term outcomes and designing therapies that achieve durable control.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2017

The Role of Heparin in Lung Cancer

Abu Arab WalidCorresponding author
Service de Chirurgie thoracique, Université de Sherbrooke, Québec, Canada
Neoplasms Cited by 7 doi:10.14302/issn.2639-1716.jn-17-1499
2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986

How this research is being cited

The 11 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cancer Recurrence, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Neoplasms (ISSN 2639-1716).

Journal editorial board
Chi Leung CHIANG · Hong Kong Diogo Moura · Portugal Argyrios Tzamalis · Greece

This page summarises published research for orientation; it is not medical or professional advice.