Aims & Scope
Journal of Etiological Diagnosis (JED) publishes mechanistic research that elucidates the molecular, cellular, and biochemical pathways underlying disease development. We focus on pathophysiological mechanisms, not clinical management or therapeutic interventions.
Research Scope
Molecular Pathogenesis
- Signaling pathway dysregulation in disease
- Gene expression alterations and epigenetic modifications
- Protein misfolding and aggregation mechanisms
- Metabolic pathway disruptions
- Cellular stress responses and adaptation
- Molecular mechanisms of disease progression
Identification of novel signaling cascades driving neurodegeneration through aberrant protein phosphorylation patterns in cellular models.
Biomarker Discovery & Validation
- Molecular biomarkers for disease mechanisms
- Proteomic and metabolomic signatures
- Circulating nucleic acids as mechanistic indicators
- Post-translational modification patterns
- Biomarker validation in disease models
- Multi-omics integration for pathway analysis
Discovery of microRNA panels reflecting inflammatory pathway activation in autoimmune disease models with mechanistic validation.
Disease Models & Mechanisms
- In vitro cellular models of disease pathways
- Animal models recapitulating disease mechanisms
- Organoid systems for mechanistic studies
- Genetic manipulation to elucidate pathways
- Model validation for mechanistic research
- Comparative pathophysiology across species
Development of CRISPR-engineered cellular models to dissect the role of specific genes in mitochondrial dysfunction pathways.
Cellular & Molecular Mechanisms
- Cell death pathways (apoptosis, necrosis, autophagy)
- Inflammatory cascade mechanisms
- Oxidative stress and redox signaling
- Mitochondrial dysfunction in disease
- Endoplasmic reticulum stress responses
- Cell-cell communication in pathology
Mechanistic analysis of how endoplasmic reticulum stress triggers inflammatory responses through specific kinase activation cascades.
Genetic & Genomic Mechanisms
Genetic variants affecting disease pathways, gene-environment interactions at molecular level, functional genomics of disease mechanisms, somatic mutations in disease progression.
Immunological Mechanisms
Immune cell signaling in disease, cytokine networks and inflammatory pathways, immune evasion mechanisms, autoimmunity molecular basis, innate and adaptive immune responses.
Microbial Pathogenesis
Host-pathogen molecular interactions, microbial virulence mechanisms, microbiome effects on host pathways, antimicrobial resistance mechanisms at molecular level.
Environmental & Toxicological Mechanisms
Molecular mechanisms of environmental toxin effects, occupational exposure pathways, chemical-induced cellular stress, environmental modulation of disease pathways.
Systems Biology Approaches
Network analysis of disease pathways, computational modeling of molecular mechanisms, multi-scale mechanistic modeling, pathway enrichment and systems-level analysis.
Methodological Innovations
Novel techniques for mechanistic investigation, advanced imaging of cellular processes, high-throughput screening for pathway analysis, innovative molecular profiling methods.
Single-Cell Mechanistic Analysis
Single-cell resolution of disease pathway heterogeneity and cellular state transitions in pathology.
Spatial Molecular Profiling
Spatial transcriptomics and proteomics revealing tissue-level mechanistic organization in disease.
AI-Driven Pathway Discovery
Machine learning approaches to identify novel disease mechanisms from multi-omics data integration.
Extracellular Vesicle Mechanisms
Molecular cargo and signaling roles of exosomes and microvesicles in disease pathogenesis.
We Do NOT Publish
Clinical Diagnosis & Management
Rationale: Clinical diagnostic protocols, patient management strategies, treatment algorithms, and clinical decision-making tools focus on practice rather than mechanistic understanding. These belong in clinical journals.
Therapeutic Interventions & Outcomes
Rationale: Drug efficacy studies, treatment protocols, clinical trials of therapies, and patient outcome analyses are clinical research, not mechanistic pathophysiology. Submit to therapeutic or clinical journals.
Epidemiological Studies Without Mechanism
Rationale: Pure epidemiological surveys, risk factor associations, or population health studies without molecular/cellular mechanistic investigation lack the pathophysiological focus of JED.
Descriptive Clinical Case Reports
Rationale: Case reports describing clinical presentations, diagnostic workups, or treatment responses without novel mechanistic insights or molecular analysis are outside our scope.
Health Services & Policy Research
Rationale: Healthcare delivery, policy analysis, cost-effectiveness studies, and health system research do not address molecular mechanisms of disease pathogenesis.
Article Types & Priorities
Expedited Review
- Original Research Articles (mechanistic studies)
- Systematic Reviews & Meta-Analyses (pathway-focused)
- Methods & Resources (novel mechanistic techniques)
- Brief Reports (significant mechanistic findings)
Regular Processing
- Short Communications (preliminary mechanisms)
- Data Notes (mechanistic datasets)
- Perspectives (mechanistic interpretation)
- Technical Notes (methodological advances)
Exceptional Cases Only
- Case Reports (only with novel mechanism)
- Opinion Pieces (mechanistic controversies)
- Commentaries (pathway debates)
- Letters (mechanistic corrections)
Editorial Standards & Requirements
Reporting Guidelines
- ARRIVE 2.0 for animal studies
- MIQE for qPCR experiments
- MIAME for microarray data
- STROBE-ME for molecular epidemiology
- PRISMA for systematic reviews
Data Requirements
- Raw data deposition in public repositories
- Complete statistical analysis details
- Reproducibility documentation
- Code availability for computational work
- Material availability statements
Ethics & Integrity
- IRB/IACUC approval for all studies
- Informed consent documentation
- Conflict of interest disclosure
- Funding source transparency
- Adherence to Helsinki Declaration
Preprint Policy
- Preprints welcomed and encouraged
- bioRxiv/medRxiv deposition supported
- No impact on novelty assessment
- Preprint DOI cited in final publication
- Version control maintained
