Aims & Scope
The Journal of Human and Animal Intestines (JHAI) publishes multidisciplinary research on intestinal structure, function, pathology, and therapeutics across human and animal models. We focus on mechanistic studies of gastrointestinal physiology, microbiome interactions, digestive disorders, and translational innovations in intestinal health.
Research Scope: Tiered Structure
Intestinal Structure & Function
- Intestinal epithelium biology and barrier function
- Intestinal stem cells and regeneration mechanisms
- Intestinal motility and neuromuscular regulation
- Intestinal absorption and metabolism pathways
- Enteric nervous system and gut-brain axis
- Intestinal permeability and tight junction dynamics
Gastrointestinal Disorders & Pathology
- Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
- Irritable bowel syndrome and functional disorders
- Intestinal cancer (colorectal, small intestine neoplasms)
- Intestinal infections and parasitic diseases
- Intestinal ischemia and vascular disorders
- Congenital intestinal anomalies (atresia, malrotation)
Intestinal Microbiome & Immunity
- Gut microbiota composition and dysbiosis
- Host-microbe interactions and metabolomics
- Intestinal immune system and mucosal immunity
- Probiotics, prebiotics, and microbiome therapeutics
- Microbiome-gut-brain axis communication
- Intestinal inflammation and immune regulation
Comparative & Translational Gastroenterology
- Animal models of intestinal disease (rodent, porcine, avian)
- Comparative intestinal anatomy and physiology
- Translational studies from bench to bedside
- Intestinal surgery and surgical innovations
- Intestinal transplantation and regenerative medicine
- Veterinary gastroenterology and livestock health
Cross-Disciplinary Integration
We welcome research integrating intestinal biology with nutrition science, pharmacology, bioengineering (intestinal organoids, tissue engineering), and computational modeling of gut physiology. Studies must maintain clear intestinal focus.
Methodological Innovations
Novel techniques in intestinal imaging (confocal, multiphoton microscopy), omics approaches (genomics, proteomics, metabolomics), advanced endoscopy, and AI-assisted diagnostics for gastrointestinal pathology are encouraged.
Nutritional Gastroenterology
Research on diet-gut interactions, nutritional interventions for intestinal disorders, intestinal hormone regulation, and nutrient absorption mechanisms. Studies must demonstrate direct intestinal effects.
Intestinal Pharmacology
Drug development targeting intestinal disorders, intestinal drug metabolism, pharmacokinetics of oral therapeutics, and novel drug delivery systems for gastrointestinal diseases.
Tier 3: Selective Frontiers
Out of Scope: Explicit Exclusions
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Hepatology & Pancreatic Research (Primary Focus) Studies where liver or pancreas is the primary organ of investigation. Exception: Research on hepatobiliary-intestinal interactions or pancreatic-intestinal axis with substantial intestinal component.
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Esophageal & Gastric Disorders (Exclusive Focus) Research limited to upper GI tract without intestinal involvement. Exception: Studies on gastroduodenal interactions or upper-to-lower GI transit mechanisms.
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Systemic Diseases Without Intestinal Manifestation Cardiovascular, renal, or pulmonary diseases lacking demonstrated intestinal pathology or gut-organ axis involvement.
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Pure Computational Studies Without Validation In silico modeling, bioinformatics analyses, or AI algorithms without experimental or clinical validation in intestinal systems.
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General Nutrition Science Dietary studies without mechanistic investigation of intestinal effects, or nutritional epidemiology lacking gastrointestinal outcome measures.
Article Types & Editorial Priorities
High-Impact Research
- Original Research Articles
- Systematic Reviews & Meta-Analyses
- Novel Methods & Protocols
- Clinical Trials (Phase II-IV)
- Translational Studies
Specialized Contributions
- Short Communications
- Data Notes & Datasets
- Technical Reports
- Perspectives & Commentaries
- Case Series (n≥5)
Limited Acceptance
- Single Case Reports
- Opinion Pieces
- Narrative Reviews (non-systematic)
- Letters to Editor
- Conference Abstracts
Editorial Standards & Requirements
Reporting Guidelines
All submissions must adhere to discipline-specific reporting standards:
Clinical trials must be prospectively registered (ClinicalTrials.gov, ISRCTN, etc.).
Data Transparency
We require data availability statements. Raw data, code, and protocols should be deposited in recognized repositories (GenBank, Dryad, Figshare, GitHub).
Microbiome studies must deposit sequence data in NCBI SRA or EBI ENA.
Ethics & Integrity
Human studies require IRB/ethics committee approval. Animal research must comply with ARRIVE guidelines and institutional IACUC approval.
We follow COPE guidelines and screen all submissions with plagiarism detection software.
Preprint Policy
We accept submissions previously posted on recognized preprint servers (bioRxiv, medRxiv, arXiv). Authors must disclose preprint DOI at submission.
Preprint posting does not constitute prior publication.
Decision Metrics & Publication Timeline
Journal Performance Indicators
Ready to Submit?
If your research aligns with our scope and meets our editorial standards, we invite you to submit your manuscript. Our editorial team provides constructive feedback to all authors, regardless of decision outcome.
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