Aims & Scope
Journal of Nervous System and Physiological Phenomena (JNPP) publishes mechanistic research on physiological systems, focusing on how neural and organ systems function at molecular, cellular, and systems levels in health and disease states.
Research Scope: Tiered Structure
These represent our primary focus areas where we actively seek high-quality mechanistic studies. Submissions in these domains receive priority editorial consideration.
Neural System Physiology
- Central nervous system electrophysiology and signal transduction
- Synaptic transmission mechanisms and plasticity
- Neural circuit function and connectivity mapping
- Sensory system physiology and signal processing
- Motor control and coordination mechanisms
- Autonomic nervous system regulation
"Voltage-gated calcium channel dynamics in hippocampal synaptic plasticity: A patch-clamp and computational modeling study"
Cellular & Molecular Neurophysiology
- Ion channel structure, function, and regulation
- Neurotransmitter receptor mechanisms and pharmacology
- Intracellular signaling cascades in neurons and glia
- Membrane potential dynamics and action potential generation
- Neuronal metabolism and energy homeostasis
- Glial cell physiology and neuron-glia interactions
"GABA receptor subunit composition regulates inhibitory synaptic strength in cortical interneurons: Electrophysiological and molecular analysis"
Integrative Systems Physiology
- Cardiovascular system regulation and hemodynamics
- Respiratory control mechanisms and gas exchange
- Renal physiology and fluid-electrolyte homeostasis
- Endocrine system function and hormonal regulation
- Gastrointestinal motility and secretion
- Thermoregulation and metabolic control
"Baroreceptor reflex modulation of sympathetic outflow: In vivo recordings and mathematical modeling of cardiovascular homeostasis"
Neurodevelopmental Physiology
- Neural circuit formation and refinement mechanisms
- Developmental electrophysiology and maturation
- Axon guidance and synaptogenesis
- Critical period plasticity and experience-dependent development
- Neurogenesis and neural stem cell physiology
- Developmental regulation of ion channel expression
"Temporal dynamics of GABAergic synapse maturation in developing neocortex: Electrophysiological characterization and functional implications"
Cross-disciplinary research and methodological innovations that advance physiological understanding. These submissions undergo standard peer review with emphasis on mechanistic insight.
Computational Physiology
- Neural network modeling and simulation
- Biophysical models of cellular function
- Systems-level computational frameworks
- Data-driven physiological modeling
- Machine learning applications in physiological data analysis
Neuroimaging Physiology
- Functional MRI and hemodynamic coupling
- Electrophysiological imaging techniques
- Calcium imaging and optical physiology
- Multimodal imaging integration
- Image-based physiological measurements
Molecular Mechanisms in Disease
- Pathophysiology of neurodegenerative processes
- Ion channel dysfunction and channelopathies
- Synaptic dysfunction mechanisms
- Metabolic dysregulation in neural tissue
- Molecular basis of physiological disorders
Experimental Methods & Tools
- Novel electrophysiological techniques
- Optogenetic and chemogenetic tools
- Advanced microscopy for physiological imaging
- Biosensor development and validation
- High-throughput physiological screening
Neuroimmune Physiology
- Immune-neural system interactions
- Microglial physiology and function
- Inflammatory signaling in neural tissue
- Blood-brain barrier physiology
- Cytokine effects on neural function
Pharmacological Physiology
- Drug effects on physiological systems
- Receptor pharmacology and signaling
- Neurotransmitter system modulation
- Pharmacokinetics in neural tissue
- Mechanism-based drug discovery
Novel research directions at the cutting edge of physiological science. Submissions in these areas undergo additional editorial review to ensure substantial mechanistic contribution and methodological rigor.
Neural Engineering & Bioelectronics
- Brain-machine interface physiology
- Neuroprosthetic device integration
- Bioelectronic medicine mechanisms
- Neural electrode interface physiology
Regenerative Neurophysiology
- Neural regeneration mechanisms
- Stem cell-derived neural physiology
- Axon regeneration and guidance
- Functional recovery mechanisms
Bioinformatics & Omics
- Transcriptomic analysis of physiological states
- Proteomic profiling in neural systems
- Metabolomic studies of neural function
- Multi-omics integration approaches
The following topics fall outside our scope and will be desk-rejected without peer review. Authors are encouraged to consider specialized clinical or applied journals for these submissions.
Clinical Case Reports
Individual patient cases without mechanistic investigation or physiological experimentation
Treatment Protocols
Clinical management guidelines, therapeutic algorithms, or treatment outcome studies without physiological mechanism analysis
Diagnostic Procedures
Clinical diagnostic techniques or biomarker validation studies without underlying physiological mechanism investigation
Epidemiological Studies
Population-based disease occurrence or risk factor analysis without experimental physiological component
Purely Behavioral Studies
Behavioral assessments or psychological interventions without neural or physiological measurements
Medical Device Reports
Device performance evaluations or clinical implementation studies without physiological mechanism investigation
Article Types & Editorial Priorities
Fast-Track Review
These article types receive expedited editorial handling and priority peer review assignment (target: first decision within 3-4 weeks).
Standard Review
These article types follow standard peer review timelines (target: first decision within 5-6 weeks).
Selective Acceptance
These article types are only considered when they present exceptional mechanistic insights or methodological innovations. Authors should contact the editorial office before submission.
Editorial Standards & Requirements
Reporting Guidelines
ARRIVE 2.0 for animal studies, CONSORT for trials, STROBE for observational studies, PRISMA for systematic reviews
Data Availability
Raw data deposition in public repositories required. Code and analysis scripts must be shared upon reasonable request
Ethics Approval
IRB/IACUC approval required for all human and animal studies. Ethics statement mandatory in manuscript
Preprint Policy
Preprint posting encouraged on bioRxiv, medRxiv, or arXiv. Does not affect consideration for publication
Reproducibility
Detailed methods, reagent information, and statistical approaches required. Replication studies welcomed
Statistical Rigor
Sample size justification, appropriate statistical tests, and effect size reporting required for all studies
Publication Metrics & Performance
Our commitment to efficient peer review and transparent publishing ensures rapid dissemination of high-quality physiological research.
Days to First Decision
Acceptance Rate
Days to Publication
Access Model
Ready to Submit?
If your research focuses on physiological mechanisms, system function, or neural processes with rigorous experimental design, we invite your submission.
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